Figure 4.

Arthritis treatment with ART-1-IL-27 liposomes. A Lewis rats arthritis model was used to i.v. administer free IL-27, ART-1-IL-27 liposomes, control-IL-27 liposomes, or ART-1 liposomes and an untreated PBS control. (A) The differences in arthritic scores of the 4 pairs of groups were significant (*P<0.01): ART-1-IL-27 liposomes v/s control rats, ART-1-IL-27 liposomes v/s ART-1 liposomes without IL-27, ART-1-IL-27 liposomes v/s control-IL-27 liposomes, and ART-1-IL-27 liposomes v/s free IL-27. (B) Photographs of the rat’s hind paw at the end of the treatment and (C) H&E-staining of hind paw sections, the histopathological features represented as: B: bone, C: cartilage, JS: joint space, P: pannus. Reprinted with permission from Elsevier, JControlled Release, Peptide-directed liposomal delivery improves the therapeutic index of an immunomodulatory cytokine in controlling autoimmune arthritis, Meka RR, Venkatesha SH, Moudgil KD. Copyright 2018.¹⁶⁸