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. 2019 Oct 29;14:8521–8542. doi: 10.2147/IJN.S216199

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© 2019 Xi et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

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Anti-arthritic efficacy of FA-PPLNPs/Mtx, PPLNPs/Mtx and free Mtx in AIA rats. (A) Scores of RA in days after administration of FA-PPLNPs/Mtx, PPLNPs/Mtx, free Mtx and saline. **P<0.01. (B) Paw thickness after all treatments. (C) AIA rat paws from the different AIA groups. Copyright © 2017. Dove Medical Press. Reprinted from Zhao J, Zhao M, Yu C, et al. Multifunctional folate receptor-targeting and pH-responsive nanocarriers loaded with methotrexate for treatment of rheumatoid arthritis. Int J Nanomedicine. 2017;12:6735-6746.¹⁷³

Abbreviations: RA, rheumatoid arthritis; MTX, methotrexate.