Figure 9.

Therapeutic effects of ASO delivered by c-agarose gel on the development of AA. Row A are photographs of the inflamed feet of AA. Row B represents the X-ray examination of the inflamed feet. Row C shows the sections of inflamed feet tissue. All the results were taken on the 15th day after ASO administration and n=10, while, the clinical indexes are summarized in the 7th column. *P<0.05 v/s AA animals without the treatment of ASO. Reprinted with permission from Elsevier: Biomaterials, Spleen-specific suppression of TNF-α by cationic hydrogel-delivered antisense nucleotides for the prevention of arthritis in animal models, Dong L, Xia S, Chen H, Chen J, Zhang J, Copyright 2009.¹⁸¹