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. 2019 Aug 22;20(11):e48336. doi: 10.15252/embr.201948336

Figure 8. Several key residues in the pore of the PC1/PC2 channel may play roles in ion conductance.

Figure 8

Structure of the PC1/PC2 complex showing the side view of S10‐S11 from the PC1 subunit and S5‐S6 from one PC2 subunit in the cryo‐EM structure of PC1/PC2 (PDB code 6A70) 42. Side chains of PC2‐L677A and N681 are shown in red and N674 in cyan. Side chains of amino acids on S11 of PC1 at this region were shown in purple for the three positively charged amino acids and in green for others. In PC1/PC2 complex, no bulky side chain from PC1 lines up with PC2‐L677A and N681 to form the restriction at this position, while R4090 of PC1 and N674 of PC2 narrow down the channel pore in the middle.