Skip to main content
. 2019 Sep 24;20(11):e48647. doi: 10.15252/embr.201948647

Figure 1. STAT3 regulates skin γδT17 cell homeostasis and their response and pathogenicity during imiquimod‐driven psoriasis.

Figure 1

Flow cytometric analysis of γδ T cells in RORγtCRE‐STAT3F/F (Cre+) and littermate control mice (Cre−). In graphs, each symbol represents a mouse and line the median. *P < 0.05, **P < 0.01, ***P < 0.001 using Mann–Whitney test.
  • A, B
    Numbers of γδT17 cells in the LN (A) and skin (B) before (steady state) and after IMQ‐induced psoriasis. Steady state: n = 8; 4 experiments, IMQ: n = 11–12; 4 experiments.
  • C
    Representative micrographs indicating ear skin sections stained with H&E before and after IMQ‐induced psoriasis (scale bar = 100 μm).
  • D
    Quantification of epidermal thickening from H&E‐stained sections. Steady‐state: n = 8; 4 experiments, IMQ: n = 11–12; 4 experiments. Each symbol is the average thickening from 5 micrographs measured in μm.