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. 2019 Sep 24;20(11):e48647. doi: 10.15252/embr.201948647

Figure EV3. Impact of STAT3 and STAT4 on Vγ4+ and Vγ4− γδT17 subsets in the lymph node and skin at steady state and during inflammation.

Figure EV3

Flow cytometric analysis of γδ T cells in RORγtCRE‐STAT3F/F (Cre+) and littermate control mice (Cre−) (A‐D) or in STAT4−/− (−/−) and littermate control mice (+/−) (E‐H). In graphs, each symbol represents a mouse and line the median. *P < 0.05, **P < 0.01, ***P < 0.001 using Mann–Whitney test.
  • A–H
    (A, B and E, F) Numbers of Vγ4+ (A and E) and Vγ4− (B and F) γδT17 cells in the LN before (steady state) and after IMQ‐induced psoriasis in RORγtCRE‐STAT3F/F (A, B) or STAT4−/− (E, F) mice. Steady state: n = 7–8; 4 experiments, IMQ: n = 11–12; 4 experiments. (C, D and G, H) Numbers of Vγ4+ (C and G) and Vγ4− (D and H) γδT17 cells in the skin before (steady state) and after IMQ‐induced psoriasis in RORγtCRE‐STAT3F/F (C, D) or STAT4−/− (G, H) mice. Steady state: n = 7–8; 4 experiments, IMQ: n = 11–12; 4 experiments.