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Long-term effects of low-dose (0.45 mg/kg per day) aspirin on platelet TXB2 and renal PGI2 synthesis. Serum TXB2 concentrations and urinary excretion of 6-keto-PGF1α were measured in three healthy subjects before, during, and after aspirin therapy. Mean values ± SEM are plotted as percentage of control measurements performed prior to aspirin administration. The arrows indicate duration of daily aspirin therapy. Redrawn from Patrignani et al. (1982).
