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. 2019 Oct 30;10:1244. doi: 10.3389/fphar.2019.01244

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Copyright © 2019 Patrono and Rocca

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Nonlinear relationship between inhibition of serum thromboxane (TX) B₂ and urinary 11-dehydro-TXB₂ excretion. In the lower left panel, individual percentage inhibition values are depicted from all on-treatment and post-treatment measurements performed in 48 healthy subjects randomized to receive aspirin 100 mg daily for 1 to 8 weeks. The nonlinear relationship between percent inhibition of serum TXB₂ and urinary 11-dehydro-TXB₂ showed that for 0 to 97% of COX-1 inhibition, TXA₂ biosynthesis in vivo was linearly inhibited by <40% and that >97% suppression of serum TXB₂ was necessary to maximally reduce TX metabolite (TXM) excretion. The upper right panel represents a detail of the left panel and is based on mathematical modeling of the experimental data. Modified and redrawn from Santilli et al. (2009), with permission from the publisher.