Table 2.
Associations of T50 with atherosclerotic cardiovascular disease and heart failure events
| Cardiovascular Disease Outcomes | Quartiles of T50, min | Per 1-SD Lower T50 (79 min) | P Value | |||
|---|---|---|---|---|---|---|
| Quartile 4 (≥364 min) | Quartile 3 (318–363 min) | Quartile 2 (264–317 min) | Quartile 1 (≤263 min) | |||
| Atherosclerotic cardiovascular disease (n=3397) | ||||||
| Events/total number | 107/847 | 142/847 | 155/852 | 167/851 | ||
| Hazard ratio (95% CI) | ||||||
| Unadjusted | Reference | 1.34 (1.05 to 1.73) | 1.56 (1.22 to 2.00) | 1.76 (1.38 to 2.24) | 1.25 (1.15 to 1.36) | <0.001 |
| Model 1a | Reference | 1.30 (1.01 to 1.68) | 1.53 (1.19 to 1.96) | 1.65 (1.28 to 2.11) | 1.23 (1.13 to 1.35) | <0.001 |
| Model 2b | Reference | 1.28 (0.99 to 1.65) | 1.42 (1.10 to 1.82) | 1.34 (1.04 to 1.73) | 1.14 (1.05 to 1.25) | 0.002 |
| Model 3c | Reference | 1.22 (0.94 to 1.57) | 1.30 (1.01 to 1.68) | 1.14 (0.88 to 1.48) | 1.07 (0.98 to 1.17) | 0.14 |
| Congestive heart failure (n=3396) | ||||||
| Events/total number | 132/ 847 | 142/ 847 | 166/ 852 | 193/ 850 | ||
| Hazard ratio (95% CI) | ||||||
| Unadjusted | Reference | 1.07 (0.84 to 1.35) | 1.32 (1.05 to 1.65) | 1.66 (1.33 to 2.07) | 1.21 (1.12 to 1.31) | <0.001 |
| Model 1a | Reference | 0.97 (0.76 to 1.23) | 1.17 (0.93 to 1.47) | 1.39 (1.10 to 1.74) | 1.14 (1.05 to 1.24) | 0.002 |
| Model 2b | Reference | 0.91 (0.71 to 1.15) | 1.06 (0.84 to 1.34) | 1.12 (0.89 to 1.41) | 1.06 (0.97 to 1.15) | 0.18 |
| Model 3c | Reference | 0.83 (0.65 to 1.06) | 0.95 (0.75 to 1.20) | 0.85 (0.67 to 1.07) | 0.95 (0.88 to 1.03) | 0.25 |
95% CI, 95% confidence interval.
a
Model 1: adjusted for age, sex, and race/ethnicity.
b
Model 2: adjusted for variables in model 1 plus history of cardiovascular disease, history of diabetes, systolic BP, use of antihypertensive medications, total cholesterol, HDL cholesterol, and current smoking.
c
Model 3: adjusted for variables in model 2 plus eGFR and 24-hour urinary protein.