Figure EV2. Ab initio modeling of shape envelopes for complete sfRNAs from DENV2 (A), ZIKV (B), and WNV (C).

• A–C
  For each RNA, forty independent ab initio shape reconstructions were generated with DAMMIN in slow mode and superimposed with DAMSEL and DAMSUP with NSD values as indicated. Four of 40 individual reconstructions are shown for each RNA in two different orientations, suggesting significant divergence among the shape reconstructions. All 40 superimposed models in each case were averaged and filtered with DAMAVER and DAMFILT to generate the final shape envelopes shown in the boxes on the left.