Kaplan–Meier disease-free survival (DFS) and overall survival (OS) curves for hepatocellular carcinoma with normal (N-HCC) or abnormal (A-HCC) AFP. A, Disease-free survival curves. The median DFS was 44.6 months (95% CI 34.2–54.9) for N-HCC and 23.6 months (95% CI 18.7–28.6) for A-HCC (P < 0.001). The one-, three-, and five-year DFS rates were 81.6%, 62.4%, and 56.5%, respectively, for N-HCC and 63.4%, 48.0%, and 42.0%, respectively, for A-HCC. B. Overall survival curves. The mean OS was 94.5 months (95% CI 91.0–97.9) for N-HCC and 81.7 months (95% CI 78.0–85.3) for A-HCC (P < 0.001). The one-, three-, and five-year OS rates were 96.4%, 90.4%, and 84.8%, respectively, for N-HCC and 88.2%, 77.5%, and 72.6%, respectively, for A-HCC. DFS, disease-free survival; OS, overall survival; N-HCC, normal α-fetoprotein HCC; A-HCC, abnormalα-fetoprotein HCC.