Table 2.
Pathologic characteristics of N-HCC a vs. A-HCC b (n = 1616).
| Variables c | Total | N-HCC a | A-HCC b | P-Value d | ||||
|---|---|---|---|---|---|---|---|---|
| No. | (%) | No. | (%) | No. | (%) | |||
| Tumor size (cm) | >5 | 505 | (32.3%) | 201 | (27.3%) | 304 | (36.7%) | <0.001 |
| Encapsulation | Yes | 1282 | (82.2%) | 605 | (82.7%) | 677 | (81.9%) | 0.685 |
| Capsular invasion | Yes | 965 | (62.0%) | 408 | (55.9%) | 557 | (67.4%) | <0.001 |
| Rupture | Yes | 120 | (7.7%) | 47 | (6.4%) | 73 | (8.8%) | 0.074 |
| Vascular invasion | Yes | 527 | (33.8%) | 178 | (24.3%) | 349 | (42.3%) | <0.001 |
| Daughter nodule | Yes | 332 | (21.3%) | 109 | (14.9%) | 223 | (27.0%) | <0.001 |
| Cirrhosis | Yes | 787 | (50.4%) | 338 | (46.2%) | 449 | (54.2%) | 0.002 |
| Necrosis | Yes | 754 | (48.5%) | 331 | (45.4%) | 423 | (51.3%) | 0.021 |
| Edmondson-Steiner grading system | Grade 1/2 | 944 | (61.8%) | 527 | (74.3%) | 417 | (50.9%) | <0.001 |
| Grade 3/4 | 584 | (38.2%) | 182 | (25.7%) | 402 | (49.1%) | ||
| T stage | T1 | 852 | (58.1%) | 456 | (66.4%) | 396 | (50.8%) | <0.001 |
| T2 | 345 | (23.5%) | 152 | (22.1%) | 193 | (24.7%) | ||
| T3a | 133 | (9.1%) | 38 | (5.5%) | 95 | (12.2%) | ||
| T3b | 50 | (3.4%) | 6 | (0.9%) | 44 | (5.6%) | ||
| T4 | 87 | (5.9%) | 35 | (5.1%) | 52 | (6.7%) | ||
| N stage | N1 | 12 | (0.8%) | 4 | (0.6%) | 8 | (1.0%) | 0.343 |
a Normal α-fetoprotein hepatocellular carcinoma b Abnormal α-fetoprotein hepatocellular carcinoma c Only patients with available data were analyzed d N-HCC vs. A-HCC; Pearson’s χ2 test was used to analyze the categorical variables.