Table 3.
Univariate and cox regression multivariate analyses of factors associated with disease-free survival (DFS) a in N-HCC b after hepatectomy.
| Variables c | Univariate | Multivariate | ||
|---|---|---|---|---|
| Median DFS a ± SE (months) | P-Value | Hazard Ratio (95% CI) | P-Value | |
| Age (>65 vs. ≤65 (year-old)) | 39.4 ± 4.6 vs. 49.2 ± 8.6 | 0.131 | ||
| Gender (male vs. female) | 41.9 ± 5.8 vs. 70.6 ± 15.7 | 0.115 | ||
| Diabetes mellitus (yes vs. no) | 45.6 ± 12.0 vs. 44.6 ± 6.3 | 0.428 | ||
| Hypertension (yes vs. no) | 41.7 ± 11.5 vs. 41.6 ± 5.0 | 0.523 | ||
| ESRD d (yes vs. no) | 76.0 ± 29.0 vs. 44.6 ± 5.4 | 0.873 | ||
| HBV surface antigen (positive vs. negative) | 47.9 ± 7.4 vs. 41.0 ± 7.1 | 0.310 | ||
| Hepatitis C virus (positive vs. negative) | 32.9 ± 5.2 vs. 46.2 ± 8.0 | 0.182 | ||
| Cigarette smoking (yes vs. no) | 37.6 ± 5.6 vs. 47.0 ± 7.0 | 0.197 | ||
| Alcohol consumption (yes vs. no) | 41.9 ± 11.8 vs. 45.6 ± 6.3 | 0.526 | ||
| Pre-OP symptoms e (yes vs. no) | 31.8 ± 5.4 vs. 60.0 ± 7.5 | 0.004 | 1.278 (0.986–1.657) | 0.064 |
| ICG-15 f (>10 vs. ≤10 (%)) | 32.7 ± 4.8 vs. 57.2 ± 7.8 | 0.002 | 1.520 (1.204–1.919) | <0.001 |
| Procedure type (Major g vs. Minor) | 28.2 ± 7.0 vs. 61.4 ± 8.0 | <0.001 | 1.017 (0.751–1.377) | 0.913 |
| Blood loss (>800 vs. ≤800 (mL)) | 30.7 ± 11.0 vs. 47.0 ± 6.3 | 0.034 | 1.095 (0.750–1.597) | 0.639 |
| OP duration (>270 vs. ≤270 (mins)) | 36.7 ± 4.2 vs. 70.6 ± 9.1 | <0.001 | 1.238 (0.964–1.591) | 0.094 |
| Complication (Major h vs. Minor/none) | 27.7 ± 10.7 vs. 46.2± 6.2 | 0.044 | 1.031 (0.699–1.520) | 0.879 |
| Albumin (≤3.5 vs. >3.5 (g/dL)) | 40.1 ± 5.6 vs. 47.0 ± 6.3 | 0.175 | ||
| Tumor size (>5 vs. ≤5 (cm)) | 26.9 ± 4.6 vs. 67.9 ± 8.7 | <0.001 | 1.823 (1.366–2.433) | <0.001 |
| Capsule (yes vs. no) | 47.0 ± 6.2 vs. 32.9 ± 5.9 | 0.147 | ||
| Capsular invasion (yes vs. no) | 41.9 ± 7.7 vs. 49.2 ± 9.2 | 0.264 | ||
| Rupture (yea vs. no) | 32.0 ± 11.9 vs. 47.9 ± 6.7 | 0.010 | 1.098 (0.709–1.701) | 0.676 |
| Vascular invasion (yes vs. no) | 22.0 ± 4.2 vs. 63.5 ± 8.9 | <0.001 | 1.460 (1.116–1.910) | 0.006 |
| Daughter nodule (yes vs. no) | 22.2 ± 2.6 vs. 61.4 ± 7.5 | <0.001 | 1.565 (1.182–2.072) | 0.002 |
| Cirrhosis (yes vs. no) | 40.1 ± 3.8 vs. 62.3 ± 9.6 | 0.040 | 1.272 (1.008–1.605) | 0.043 |
| Necrosis (yes vs. no) | 40.6 ± 3.8 vs. 63.5 ± 8.8 | 0.061 | ||
| Edmondson–Steiner grading system(grade 3/4 vs. grade 1/2) | 37.4 ± 7.6 vs. 47.0 ± 6.2 | 0.101 | ||
a Disease-free survival b Normal α-fetoprotein hepatocellular carcinoma c Only patients with available data were analyzed d End-stage renal disease e Include HCC presenting with anemia, jaundice, palpable mass, or ascites f Indocyanine green retention test at 15 min g Includes tri-segmentectomy, right/left lobectomy, and extended right/left lobectomy h Includes grade III-IV surgical complications.