Table 1.
Summary of stilbene disulfonic acid derivatives activities. IN-catalyzed 3′-P and ST were monitored using a gel-based assay. IN-catalyzed 3′-P corresponds to the cleavage of the terminal dinucleotide at the 3′-end of the viral DNA mimic, while ST corresponds to the integration of the 3′-P product within another DNA molecule. Values derived from at least three independent experiments.
| In Vitro (µM, IC50 +/−SD) | Ex Vivo (µM) | |||||
|---|---|---|---|---|---|---|
| NSC # | R | 3’-P | ST | Antiviral Activity | Cytotoxicity | Selectivity Index |
| EC50 | CC50 | SI | ||||
| 34931 |
|
0.32 ± 0.12 | 0.18 ± 0.07 | 3.07 | 59.0 | 19.2 |
| 34933 |
|
1.1 ± 0.3 | 0.5 ± 0.2 | 0.60 | >100 | >166 |
| 47745 |
|
3.2 ± 1.5 | 3.1 ± 1.7 | 15.3 | >100 | >6.5 |
| 163175 |
|
>111 | >111 | ND | ND | ND |
| 163 |
|
>111 | >111 | ND | ND | ND |
Originally known as Cancer Chemotherapy National Service Center number, the NSC number (NSC #) is an identifying number assigned by the DTP.