Skip to main content
. 2019 Oct 15;24(20):3711. doi: 10.3390/molecules24203711

Table 2.

The results from the biochemical and biophysical binding assays for ligands 17a–k. The inhibition concentration at 50% (IC50) is given as well as the dissociation constant (KD).

Code R (+)-enantiomer (−)-enantiomer
IC50/nM KD/µM IC50/nM KD/µM
17a graphic file with name molecules-24-03711-i019.jpg 26 ± 8 212 ± 25 54 ± 3 n.d.*
17b graphic file with name molecules-24-03711-i020.jpg 26 ± 4 131 ± 15 78 ± 3 n.d.
17c graphic file with name molecules-24-03711-i021.jpg 41 ± 7 204 ± 23 37 ± 10 74 ± 4
17d graphic file with name molecules-24-03711-i022.jpg 77 ± 3 130 ± 29 18 ± 1 76 ± 5
17e graphic file with name molecules-24-03711-i023.jpg 64 ± 6 213 ± 4 30 ± 11 130 ± 8
17f graphic file with name molecules-24-03711-i024.jpg 60 ± 1 127 ± 14 21 ± 5 536 ± 90
17g graphic file with name molecules-24-03711-i025.jpg 122 ± 25 223 ± 42 94 ± 20 n.d.
17h graphic file with name molecules-24-03711-i026.jpg 74 ± 1 188 ± 22 48 ± 2 n.d.
17i graphic file with name molecules-24-03711-i027.jpg 80 ± 7 161 ± 22 59 ± 5 n.d.
17j graphic file with name molecules-24-03711-i028.jpg 69 ± 14 69 ± 14 71 ± 15 n.d.
17k graphic file with name molecules-24-03711-i029.jpg 54 ± 8 156 ± 8 46 ± 5 142 ± 11

*n.d. – not determined.