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. 2019 Oct 15;24(20):3712. doi: 10.3390/molecules24203712

Table 1.

Broussonetine M (3) and analogues synthesized from different cyclic nitrones and alcohols.

Entry Cyclic Nitrone Pyrrolidine Yield a Alcohol Product Yield b
1 graphic file with name molecules-24-03712-i001.jpg graphic file with name molecules-24-03712-i002.jpg 64% graphic file with name molecules-24-03712-i003.jpg graphic file with name molecules-24-03712-i004.jpg 43%
2 graphic file with name molecules-24-03712-i005.jpg graphic file with name molecules-24-03712-i006.jpg 43%
3 graphic file with name molecules-24-03712-i007.jpg graphic file with name molecules-24-03712-i008.jpg 65% graphic file with name molecules-24-03712-i009.jpg graphic file with name molecules-24-03712-i010.jpg 41%
4 graphic file with name molecules-24-03712-i011.jpg graphic file with name molecules-24-03712-i012.jpg 45%
5 graphic file with name molecules-24-03712-i013.jpg graphic file with name molecules-24-03712-i014.jpg 64% graphic file with name molecules-24-03712-i015.jpg graphic file with name molecules-24-03712-i016.jpg 40%
6 graphic file with name molecules-24-03712-i017.jpg graphic file with name molecules-24-03712-i018.jpg 41%
7 graphic file with name molecules-24-03712-i019.jpg graphic file with name molecules-24-03712-i020.jpg 71% graphic file with name molecules-24-03712-i021.jpg graphic file with name molecules-24-03712-i022.jpg 43%
8 graphic file with name molecules-24-03712-i023.jpg graphic file with name molecules-24-03712-i024.jpg 43%

a Total yield in 3 steps starting from cyclic nitrones to the corresponding pyrrolidine. b Total yield in 2 steps starting from pyrrolidine cores to broussonetine M or its analogues.