Table 1.

Indications for allogeneic hematopoietic stem cell transplantation in sickle cell disease [34,35,36,37].

Indication		HLA-Matched Related Donor	Alternative Donor*
Predictors for Increased Mortality	≥2 VOC/year	X	X
	Recurrent acute chest syndrome	X	X
	Stroke	X	X
	Cognitive impairment + Abnormal cerebral MRI	X	X
	TRJV ≥ 2.7 m/s	X	X
	Sickle nephropathy	X
Predictors for Increased Morbidity	Red blood cell alloimmunization	X
	Recurrent priapism	X
	Osteonecrosis of multiple joints	X

HLA, human leukocyte antigen; VOC, vaso-occlusive crisis; MRI, magnetic resonance imaging: TRJV, tricuspid regurgitant jet velocity. * Despite hydroxyurea and/or chronic red blood cell transfusion therapy.