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. 2019 Oct 1;8(10):1565. doi: 10.3390/jcm8101565

Table 2.

Reduced-intensity conditioning regimens in adults with SCD.

Conditioning Regimen GVHD Prophylaxis N Age
(years)		 Graft
Source		 Event-free
Survival		 Overall
Survival		 aGVHD
(≥grade 2)		 cGVHD
(≥moderate)		 Reference
Fludarabine (150 mg/kg)
Busulfan (3.2 mg/kg)
Cy (29 mg/kg)
ATG (15 mg/kg)
Total body irradiation (200 cGy)

  • Cy 33 mg/kg/day on day +3, 4

  • Sirolimus

 20 20–45 20 MRD 100% 100% 5% 0% [50]
Fludarabine (175 mg/m2)
Busulfan (13.2 mg/kg)
ATG (6 mg/kg)

  • MTX 7.5 mg/m2/day on day +1, 3, 6, 11

  • Cyclosporine or tacrolimus

 22 17–36 17 MRD
5 MUD		 82% 91% 18% 14% [35]

SCD, sickle cell disease; aGVHD, acute graft versus host disease; cGVHD, chronic graft versus host disease; Cy, cyclophosphamide; ATG, antithymocyte globulin; cGy, centigray; MRD, matched related donors; MUD, matched unrelated donors.