Table 3.
Comparison of antifungal in vitro activity of VOR and its salts against drug-susceptible (Gu4 and B3) and multidrug-resistant (Gu5 and B4) Candida albicans clinical strains. MICs were determined by the microtiter serial twofold dilution method in RPMI-1640 medium.
| Comp. | MIC (μg·mL−1) | |||
|---|---|---|---|---|
| Gu4 | Gu5 | B3 | B4 | |
| VOR 1 | 0.125 | 4.0 | 1.0 | 4.0 |
| [VOR][Cl] 2 | 0.031 | 0.5 | 1.0 | 4.0 |
| [VOR][dl-Lac] 5a | 0.062 | 0.5 | 0.5 | 2.0 |
| [VOR][l-Lac] 5b | 0.031 | 0.25 | 0.5 | 2.0 |
| [VOR][Ac-l-Val] 5c | 0.062 | 0.5 | 1.0 | 4.0 |
| [VOR][l-Val] 5d | 0.031 | 0.25 | 0.5 | 2.0 |