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. 2019 Oct 16;24(20):3721. doi: 10.3390/molecules24203721

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Scheme of isoprenoid biosynthesis up to isopentenyl pyrophosphate (IPP). The dotted, red arrow indicates the hypothetical IPP Biosynthesis Pathway previously mentioned in the text, starting from intermediate metabolites of the pentose phosphate pathway in Synechocystis sp. and a possibility that has not been investigated to date in any pathogenic protozoan [70]. BCAT/LeuT/LeuDH (EC 2.6.1.42/2.6.1.6/1.4.1.9); BCKADH/VOR complex (EC 1.2.4.4, 2.3.1.168, 1.8.1.4/1.2.7); IVD/ACADM (EC 1.3.8.4/1.3.8.7); MCCase (EC 6.4.1.4); MGCH (EC 4.2.1.18); HMGS (EC 2.3.3.10); HMGR (EC 1.1.1.34/1.1.1.88); MVK (EC 2.7.1.36); PMK (EC 2.7.4.2); MVD (EC 4.1.1.33); DXS (EC 2.2.1.7); DXR (EC 1.1.1.267); IspD (EC 2.7.7.60); IspE (EC 2.7.1.148); IspF (EC 4.6.1.12); IspG (EC 1.17.7.1/1.17.7.3); IspH (EC 1.17.7.4) Based on information from Kyoto Encyclopedia of Genes and Genomes database [87].