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. 2019 Oct 16;24(20):3721. doi: 10.3390/molecules24203721

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Scheme of ubiquinone biosynthesis. UQ biosynthesis from 4-hydroxybenzoate. In the figure depicting the metabolic pathways, the transformation of the cofactor SAM to S-adenosyl-l-homocysteine (SAH) for methylation is indicated. UbiC. Chorismate-pyruvate lyase, EC: 4.1.3.40; UbiA/Coq2. EC: 4-Hydroxybenzoate polyprenyltransferase, 2.5.1.39; UbiD. 4-Hydroxy-3-polyprenylbenzoate decarboxylase, EC: 4.1.1.98; Coq7/UbiI. 2-Polyprenylphenol 6-hydroxylase, EC: 1.14.13.240; UbiH/Coq6. UQ biosynthesis monooxygenase/2-octaprenyl-6-methoxyphenol hydroxylase, EC: 1.14.13.-; UbiE/Coq5. 2-Methoxy-6-polyprenyl-1,4-benzoquinol methylase, EC: 2.1.1.201; UbiF/Coq7. 3-Demethoxyubiquinol 3-hydroxylase, EC: 1.14.99.60; UbiG/Coq3. Polyprenyldihydroxybenzoate methyltransferase/3-demethylubiquinol, 3-O-methyltransferase/2-polyprenyl-6-hydroxyphenyl methylase/3-demethylubiquinone-9 3-methyltransferase, EC: 2.1.1.114/2.1.1.64/2.1.1.222/. Data from the Kyoto Encyclopedia of Genes and Genomes database [87].