Table 1.
Patient characteristic: Histological analysis.
| CNI Nephrotoxicity | x < 25% (n = 35) | x ≥ 25% (n = 20) | p-Value |
|---|---|---|---|
| Age (years, mean ± SD) | 57.8 ± 12.4 | 50.2 ± 20.2 | 0.014 a |
| Male sex, n (%) | 24 (68.6) | 12 (60) | 0.566 b |
| BMI (kg/m2, mean ± SD) | 25.5 ± 5.2 | 25.6 ± 5.3 | 0.981 a |
| Prednisolone dose (mg, mean ± SD) | 10.0 ± 6.3 | 14.9 ± 17.5 | 0.239 a |
| Living donor transplantation, n (%) | 26 (74.3) | 14 (70) | 0.761 b |
| ESP, n (%) | 9 (25.7) | 1 (5) | 0.075 b |
| Combined RTx + liver Tx, n (%) | 3 (8.6) | 1 (5) | 1 b |
| Previous Tx, n (%) | 3 (8.6) | 0 | 0.293 b |
| ABOi, n (%) | 4 (11.4) | 2 (10) | 1 b |
| CIT (hours, mean ± SD) | 9.2 ± 5.0 | 8.5 ± 5.0 | 0.669 a |
| WIT (min, mean ± SD) | 32.5 ± 8.1 | 32.5 ± 5.4 | 0.418 a |
| DGF | 11 (31.4) | 2 (10) | 0.107 b |
| Donor data | |||
| Male donor sex, n (%) | 13 (47,1) | 14 (70) | 0.026 b |
| Donor age (years, mean ± SD) | 61.1 ± 15.7 | 52.2±14.7 | 0.073 a |
| Time from RTx to biopsy (days) | 63 (3–2877) | 223 (10–5057) | 0.059 c |
Patients with a CNI nephrotoxicity < 25% were observed to be older and received more female allografts; CNI, calcineurin inhibitor; BMI, body mass index; ESP, European senior program; RTx, renal transplantation, Tx, transplantation; ABOi, ABO incompatible transplantation; CIT, cold ischemia time, WIT, warm ischemia time, DGF, delayed graft function; a Student’s t-test; b Fisher’s exact test; c Mann–Whitney U test.