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. 2019 Oct 9;11(10):581. doi: 10.3390/toxins11100581

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Schematic diagram of structures of metalloproteinase (MP) genes expressed in habu venom glands. svMP03-VMP-III-like (A), svMP01-HV1 (B), svMP02-flavorase (C), svMP09-HR1b-related (D), svMP05-HR1a-relate (E), svMP11-NaMP (F), svMP04-jerdonitin-like (G), svMP10-elegantin-like (H), svMP07-HR2a-related (I), svMP08-flavoviridin (J), and svMP06-H2-protease (K) are shown with validated transcript variants, verified as expressed in the venom gland. Initiation and stop-codons are marked with “M” and slashes, respectively. Active sites are shown with red arrowheads located in exon 11. The original transcripts predicted by the gene models are underlined. Both svMP08-v1 and v2 are original transcripts, of which amino acid 275 are indicated by E(Glu) and K (Lys), respectively. Numbers of transcript variants and the type of metalloproteinases are shown on the right.

Schematic diagram of structures of metalloproteinase (MP) genes expressed in habu venom glands. svMP03-VMP-III-like (A), svMP01-HV1 (B), svMP02-flavorase (C), svMP09-HR1b-related (D), svMP05-HR1a-relate (E), svMP11-NaMP (F), svMP04-jerdonitin-like (G), svMP10-elegantin-like (H), svMP07-HR2a-related (I), svMP08-flavoviridin (J), and svMP06-H2-protease (K) are shown with validated transcript variants, verified as expressed in the venom gland. Initiation and stop-codons are marked with “M” and slashes, respectively. Active sites are shown with red arrowheads located in exon 11. The original transcripts predicted by the gene models are underlined. Both svMP08-v1 and v2 are original transcripts, of which amino acid 275 are indicated by E(Glu) and K (Lys), respectively. Numbers of transcript variants and the type of metalloproteinases are shown on the right.