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. 2019 Oct 15;24(20):3705. doi: 10.3390/molecules24203705

Figure 5.

Figure 5

Effects of 6-shogaol on AGEs-induced production of IL-6 and ICAM-1. Sub-confluent HGFs were pre-treated with 6-shogaol (5 or 10 μM) for 1 h and cultured with AGEs (500 μg/mL) or BSA (500 μg/mL) for 48 h. NAC (1 mM) was also added into the HGF culture with AGEs. The amounts of IL-6 (A) in the supernatant and ICAM-1 (B) in the cell lysate were determined using their respective ELISA kits as described in the Materials and Methods section. Data are expressed as the mean ± SD of 6 independent experiments (** p < 0.01).