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. 2019 Oct 22;11(10):971. doi: 10.3390/v11100971

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) Schematic genome organization of novel picornavirus (Macaca fascicularis picornavirus 1 or Mafapivirus 1) identified from captive cynomolgus macaque (LMF17) indicating the cleavage sites and protein domains. (B) The predicted internal ribosome entry site (IRES) hybridization structure predicted by mfold software shows that this virus contains Type II IRES recognized by the conserved structure of Y-shaped J–K domains. Colors of the structure indicate the secondary structure in predicted IRES; Green: Stems (canonical helices), red: Multiloops (junctions), yellow: Interior loops, blue: hairpin loops, and orange: 5’ and 3’ unpaired region. The phylogenetic trees of Mafapivirus 1 were plotted for (C) P1 region, (D) 2C region, and (E) 3CD region. The tree was drawn to scale, with branch lengths measured in the number of changes per amino acid site. Nodes in the tree represent % of bootstrapping value (1000 rounds).