Table 5.
Estimated creatinine clearance (CrCl) and estimated glomerular filtration rate (eGFR) on study day 7
| Physiologic variables |
TGW Median (IQRa) |
CGM Median (IQR) |
TGW/CGM, % | p valueb |
|---|---|---|---|---|
| Serum Creatinine (mg/dL) | 0.80 (0.80, 0.88) | 1.05 (1.00, 1.18) | 76 | 0.002 |
| CrCl Cockcroft‐Gault (mL/min) | 204 (120, 218) | 108 (83, 125) | 188 | 0.008 |
| eGFR MDRD (mL/min/1.73 m2) | 130 (117, 142) | 89 (79, 98) | 146 | 0.002 |
| eGFR CKD‐EPI (mL/min/1.73 m2) | 133 (124, 142) | 114 (109, 118) | 116 | 0.003 |
| CrCl Cockcroft‐Gault [TGW = F] (mL/min)c | 174 (102, 185) | 109 (83, 125) | 160 | 0.035 |
| eGFR MDRD [TGW = F] (mL/min/1.73 m2)c | 97 (86, 105) | 89 (79, 98) | 109 | 0.442 |
| eGFR CKD‐EPI [TGW = F] (mL/min/1.73 m2)c | 107 (100, 118) | 98 (81, 106) | 109 | 0.315 |
CGM, cisgender men; CKDEPI, Chronic Kidney Disease Epidemiology Collaboration equation; IQR, interquartile range (lower quartile, upper quartile); MDRD, Modification of Diet in Renal Disease Study equation; TGW, transgender women.
a
Interquartile range
b
Exact 2‐sided p value, Wilcoxon rank sum test, comparing TGW and CGM
c
CrCL and eGFR estimated using the female term replacing the male term in the equation for TGW.