Figure 4.

PSD-95 enhances CDI in recombinant and native receptors. a, Whole-cell current recordings from cells expressing GluN1–2a and the indicated GluN2A and PSD-95 constructs in 0 (black) and 1.8 mm Ca²⁺ (red), overlaid and normalized to peak; shaded area highlights CDI, and bar graph summary of data; *p < 0.05, Mann–Whitney U test. b, Whole-cell current recordings from dissociated hippocampal neurons (15–20 d in vitro) transfected with the indicated shRNA constructs. Glutamate elicited currents recorded in the continuous presence of CNQX and ifenprodil, and the bar graph summary of data; *p < 0.05, Mann–Whitney U test.