Table 1.

Structures and Inhibition effect on COL1A1 of target compounds.

Code	X	R1	R2	Inhibition Rate a
1	-	-	-	18.5% ± 1.1%
3a	CH2	H	COOCH3	24.7% ± 10.0%
3b	CO	H	COOCH3	13.9% ± 8.3%
3c	SO2	H	COOCH3	30.6% ± 18.1%
4a	CH2	H	CH2OH	31.5% ± 7.5%
4b	CO	H	CH2OH	21.6% ± 5.2%
4c	SO2	H	CH2OH	13.9% ± 2.0%
7a	NHCOCH2	H	COOCH3	39.5% ± 7.1%
7b	CH2NHCOCH2	H	COOCH3	22.7% ± 8.5%
7c	NHCOCH2	p-F	COOCH3	45.2% ± 3.6%
7d	NHCOCH2	p-Cl	COOCH3	45.9% ± 2.2%
7e	NHCOCH2	p-Br	COOCH3	51.9% ± 3.1%
7f	NHCOCH2	p-CH3	COOCH3	47.0% ± 9.8%
7g	NHCOCH2	p-CF3	COOCH3	43.4% ± 11.2%
7h	NHCOCH2	p-NO2	COOCH3	29.8% ± 9.2%
7i	NHCOCH2	2,6-di-CH3	COOCH3	24.0% ± 6.9%
8a	NHCOCH2	H	CH2OH	51.0% ± 2.8%
8b	CH2NHCOCH2	H	CH2OH	40.4% ± 5.2%
8c	NHCOCH2	p-F	CH2OH	43.6% ± 1.8%
8d	NHCOCH2	p-Cl	CH2OH	42.0% ± 19.2%
8e	NHCOCH2	p-Br	CH2OH	50.6% ± 17.1%
8f	NHCOCH2	p-CH3	CH2OH	25.6% ± 5.6%
8g	NHCOCH2	p-CF3	CH2OH	32.3% ± 32.3%
8h	NHCOCH2	p-NO2	C H2OH	22.5% ± 13.0%
8i	NHCOCH2	2,6-di-CH3	CH2OH	6.0% ± 14.5%
EGCG b	-	-	-	27.5% ± 7.9%
DMSO	-	-	-	2.9% ± 0

^a The inhibition rate of COL1A1 promotor’s activity in LX-2 cells at the concentration of 80 μM; ^b The inhibition rate of COL1A1 promotor’s activity in LX-2 cells at the concentration of 25 μM.