Table 1.
Compound | Virus | Cell Line | Time (h) | CC50 (mM) | EC50-1 (mM) | EC50-2 (mM) | SI |
---|---|---|---|---|---|---|---|
Obatoclax | HSV-2 | RPE | 72 | 1.23 ± 0.02 | 0.10 ± 0.02 | 12 | |
Emetine | HSV-2 | RPE | 72 | 1.12 ± 0.07 | 0.03 ± 0.01 | 37 | |
Niclosamide | HSV-2 | RPE | 72 | 1.31 ± 0.02 | 0.43 ± 0.04 | 3 | |
Ganciclovir | HSV-2 | RPE | 72 | >30 | 0.04±0.01 | >750 | |
Obatoclax | EV1 | RPE | 48 | 3.21 ± 0.04 | 0.12 ± 0.01 | 25 | |
Emetine | EV1 | RPE | 48 | >30 | 0.12 ± 0.04 | >300 | |
Homoharringtonine | EV1 | RPE | 48 | >30 | 0.14 ± 0.03 | >300 | |
Brequinar | HIV-1 | TZM-bl | 24 | >30 | 0.04 ± 0.01 | >750 | |
Suramin | HIV-1 | TZM-bl | 24 | >30 | 0.08 ± 0.03 | >375 | |
Obatoclax | RVFV | RPE | 24 | >30 | 0.04 ± 0.01 | 0.32 ± 0.09 | >100 |
Emetine | RVFV | RPE | 24 | >30 | 0.10 ± 0.02 | 0.43 ± 0.10 | >75 |
Obatoclax | HMPV | RPE | 96 | 0.60 ± 0.04 | 0.12 ± 0.02 | 6 | |
Emetine | HMPV | RPE | 96 | 1 | 0.14 ± 0.05 | 10 | |
Obatoclax | FLUAV | RPE | 24 | 3.11 ± 0.09 | 0.04 ± 0.01 | 0.10 ± 0.01 | 31 |
Emetine | FLUAV | RPE | 24 | >30 | 0.13 ± 0.05 | 0.12 ± 0.03 | >300 |