Table 4.
Proportion of therapeutic intervention or disease modifying therapy initiation by three years of age and probability by five years of age.
| All | SS/SB° | SC/SB+ | P Value † | |
|---|---|---|---|---|
|
First transfusion by 3 years by 5 years |
32.8% (30.6–35.2) 50.1% (47.6–52.6) |
43.8% (41.0–46.2) 65.2% (62.3–68.0) |
4.8% (3.2–7.3) 1.8% (9.1–15.2) |
<0.001 |
|
Splenectomy by 3 years by 5 years |
1.9% (1.4–2.7) 5.1% (4.1–6.3) |
2.7% (1.9–3.8) 7.0% (5.6–8.7) |
0 0.3% (0.04–1.9) |
<0.001 |
|
Cholecystectomy by 3 years by 5 years |
0.1% (0.03–0.5) 2.7% (2.0–3.7) |
0.2% (0.04–0.7) 3.7% (2.7–5.1) |
0 0 |
<0.001 |
|
Chronic Transfusion program * by 3 years by 5 years |
7.0% (5.9–8.4) 13.2% (11.6–15.0) |
9.7% (8.1–11.6) 18.4% (16.2–20.8) |
0.2% (0.03–1.6) 0.2% (0.03–1.6) |
<0.001 |
|
Hydroxyurea by 3 years by 5 years |
1.4% (0.9–2.1) 9.8% (8.4–11.5) |
1.9% (1.3–2.9) 13.7% (11.7–15.9) |
0 0 |
<0.001 |
* A chronic transfusion program was defined by a duration > 3 months, † log-rank test for comparison of SS/SB° versus SC/SB+ patients at 5 years.