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. 2019 Sep 27;11(10):567. doi: 10.3390/toxins11100567

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Summary of CrzA in Aspergillus species. (A) A phylogenetic tree of the CrzA homologs identified in 23 fungal species including A. flavus AFL3357 (AFL2T_09134), A. oryzae RIB40 (AO090001000491), A. fumigatus Af293 (Afu1g06900), A. nidulans FGSC4 (AN5726), A. niger CBS 513.88 (An18g05920), A. clavatus NRRL 1 (ACLA_027670), A. sydowii (Aspsy1_0149570), A. tubingensis CBS 134.48 (Asptu1_0114323), A. acidus CBS 106 47 (Aspfo1_0139906), A. brasiliensis CBS 101740 (Aspbr1_0197410), A. versicolor CBS 583.65 (Aspve1_0132792), A. kawachii (Aspka1_0180272), A. carbonarius ITEM 5010 (Acar5010_128721), A. aculeatus ATCC16872 (Aacu16872_028665), A. terreus NIH2624 (ATET_02928), A. wentii DTO 134E9 (Aspwe1_0050154), A. zonatus (Aspzo1_0014943), A. glaucus CBS 516 65 (Aspgl1_0031266), Neosartorya fischeri NRRL 181 (NFIA_017790), Penicillium digitatum Pd1 (XP_014531047.1), Neurospora crassa OR74A (XP_962085), Magnaporthe oryzae 70-15 (MGG_05133), and Fusarium graminearum PH-1 (FGSG_01341). A phylogenetic tree of CrzA homologs (or orthologs) was generated by the Clustal Omega package (https://www.ebi.ac.uk/Tools/msa/clustalo/). The tree result was submitted to iTOL (http://itol.embl.de/) to generate the figure. (B) Domains of the CrzA homologs in fungal species. NLS (Nuclear Localization Sequence) and NES (Nuclear Export Signal)