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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Curr Opin Microbiol. 2019 May 6;51:22–29. doi: 10.1016/j.mib.2019.03.002

Table 1.

Natural products from fungi with a homolog of their target protein as the self-resistance gene within their BGC

Compound Organism Self-resistance gene Activity Ref.
Lovastatin A. terreus IvrA (HMG-CoA reductase) Treats hypercholesterolemia by inhibiting HMG-CoA reductase [42,48]
Mycophenolic acid Penicillium brevicompactum mpaF(IMP dehydrogenase) Immunosuppressive [43]
Fumagillin A. fumigatus AfuA_8g00460 (methionine amino peptidase I)
AfuA_8g00410 (methionine amino peptidase II)		 anti-angiogenesis [44,45]
Sporiofungin Pezicula radicicola prfks1a (glucan synthase FKS1) Antifungal [46]
Fellutamide A. nidulans inpE (β6 proteasome subunit) Proteasome inhibitor [47]
Aspterric acid A. terreus aspD (dihydroxyacid dehydratase) Herbicide – Inhibition of the DHAD enzyme involved in the branched-chain amino acid biosynthetic pathway in plants [48]