Table 2:
Comparison of diagnosis, clinical utility, and characteristics between NICU and PICU patients who received rWGS
| Comparative Factor | All patients | Diagnosed patients | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| NICU (n=24) | PICU (n=38) | p | NICU (n=10) | PICU (n=17) | p | |||||
| Diagnostic Utility | 10 | 41.7% | 18 | 47.4% | 0.66 | |||||
| Clinical Utility | 7 | 29.2% | 13 | 34.2% | 0.68 | 7 | 70.0% | 12 | 70.6% | 1 |
| Multiple congenital anomalies | 9 | 37.5% | 5 | 13.2% | 0.03 | 3 | 30.0% | 3 | 17.6% | 0.64 |
| Primary system involved | ||||||||||
| Neurologic | 6 | 25.0% | 8 | 21.1% | 0.72 | 3 | 30.0% | 5 | 29.4% | 1 |
| Hepatic | 2 | 8.3% | 1 | 2.6% | 0.55 | 1 | 10.0% | 0 | 0.0% | 0.37 |
| Cardiac | 2 | 8.3% | 6 | 15.8% | 0.47 | 0 | 0.0% | 5 | 29.4% | 0.12 |
| Hematologic | 1 | 4.2% | 1 | 2.6% | 1 | 0 | 0.0% | 0 | 0.0% | 1 |
| Gastrointestinal | 1 | 4.2% | 0 | 0.0% | 0.39 | 1 | 10.0% | 0 | 0.0% | 0.37 |
| Endocrine/Biochemical | 1 | 4.2% | 3 | 7.9% | 0.65 | 1 | 10.0% | 1 | 5.9% | 1 |
| Musculoskeletal | 1 | 4.2% | 0 | 0.0% | 0.39 | 1 | 10.0% | 0 | 0.0% | 0.37 |
| Pulmonary | 1 | 4.2% | 2 | 5.3% | 1 | 0 | 0.0% | 0 | 0.0% | 1 |
| Support required | ||||||||||
| Ionotropic Support | 12 | 50.0% | 19 | 50.0% | 1 | 4 | 40.0% | 6 | 35.3% | 1 |
| Respiratory Support | 23 | 95.8% | 27 | 71.1% | 0.02 | 10 | 100.0% | 11 | 64.7% | 0.06 |
| Intubated | 19 | 79.2% | 23 | 60.5% | 0.12 | 7 | 70.0% | 9 | 52.9% | 0.45 |
| ECMO | 2 | 8.3% | 4 | 10.5% | 1 | 2 | 20.0% | 2 | 11.1% | 0.61 |
| Antimicrobial Treatment | 21 | 87.5% | 33 | 86.8% | 1 | 10 | 100.0% | 14 | 82.4% | 0.27 |
| >5 Subspecialty consults | 10 | 41.7% | 11 | 28.9% | 0.41 | 5 | 50.0% | 2 | 11.8% | 0.06 |
| Mortality | 6 | 25.0% | 5 | 13.2% | 0.31 | 1 | 10.0% | 0 | 0.0% | 0.37 |