Table 6.

Impact of sex on the expression of KEGG pathways in human and mouse MGs

Ontology	M Genes ↑	F Genes ↑	M z-score	F z-score
Human
Pyrimidine metabolism	3	1	4.09	0.57
N-Glycan biosynthesis	2	0	3.91	−0.55
Base excision repair	1	1	2.35	1.86
Ribosome	1	4	1.01	4.78
Spliceosome	0	4	−0.75	3.73
Purine metabolism	2	3	1.64	2.15
Alzheimer’s disease	0	3	−0.85	2.1
Mouse
Metabolic pathways	161	70	6.8	−0.69
Peroxisome	23	3	6.17	−1.07
Oxidative phosphorylation	27	0	5.35	−2.92
Proteasome	13	3	4.69	0
Lysosome	26	7	4.68	−0.47
PPAR signaling pathway	16	5	3.54	−0.11
Leukocyte transendothelial migration	6	21	−1.49	4.93
NOD-like receptor signaling pathway	3	13	−1.13	4.59
Toll-like receptor signaling pathway	5	18	−1.49	4.43
Focal adhesion	13	26	−1.24	3.68
RIG-I-like receptor signaling pathway	5	12	−0.56	3.51
Adherens junction	5	12	−0.63	3.4

KEGG pathways were selected after analyses of non-transformed data. Human pathways contained ≥ 2 genes, and those of mice ≥ 16 genes. Pathways with z-scores > 2 are highlighted in bold.