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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Psychopharmacology (Berl). 2019 Jun 13;236(11):3371–3382. doi: 10.1007/s00213-019-05297-x

Figure 3. Blood Pressure by Drug and Time.

Figure 3.

Figure 3.

Points display standing diastolic (3A) and systolic (3B) blood pressure (BP) by Drug and Time. Error bars represent +−1 SE of the Drug effect from separate covariate adjusted General Linear Models at each time point. We analyzed standing diastolic and systolic BP in separate General Linear Models with repeated measures for Drug and Time and baseline BP (mean-centered averaged across visits) as a between-subjects regressor. Prazosin produced a significant reduction in both diastolic and systolic BP overall (p’s < .001). Furthermore, prazosin produced a significant reduction in diastolic BP at both 1-hour (p =.008) and 3-hour (p < .001). Prazosin produced a significant reduction in systolic BP by 3-hours (p < .001), but non-significant change at 1-hour (p = .067), consistent with the known greater effects on diastolic than systolic BP. See Supplement for additional analyses.

+p < .10; *p < .05; **p < .01; ***p < .001