Table 1:
Characteristics of dry eye participants with or without Sjögren’s syndrome in the Penn Sjögren’s International Collaborative Clinical Alliance (SICCA) study cohort
| Baseline Characteristics | No Sjögren’s syndrome* (Non-SS)(N=129) | Sjögren’s syndrome** (SS) (N=81) | P-value |
|---|---|---|---|
| Age (years): Mean (SD) | 50.6 (12.2) | 53.6 (14.3) | 0.11 |
| Sex: Male (%) | 10 (7.8%) | 8 (9.9%) | 0.62 |
| Race | |||
| White | 115 (89.8%) | 70 (86.4%) | |
| Black | 9 (7.0%) | 9 (11.1%) | |
| Asian | 3 (2.3%) | 1 (1.2%) | |
| Hispanic/Latino | 1 (0.8%) | 1 (1.2%) | |
| Smoking status | |||
| Never | 76 (58.9%) | 47 (58.0%) | |
| Former | 44 (34.1%) | 30 (37.0%) | |
| Current | 9 (7.0%) | 4 (4.9%) | |
| Schirmer test (mm): mean (SD)┼ | 10.6 (8.7) | 7.2 (6.1) | 0.001 |
| Total Ocular Staining Score (OSS): mean (SD) | 4.8 (2.9) | 7.5 (3.2) | <0.0001 |
| Tear Break-up Time (seconds)***┼ | 0.0005 | ||
| 3–4 | 46 (35.9%) | 15 (18.5%) | |
| 5–6 | 14 (10.9%) | 11 (13.6%) | |
| 7–9 | 20 (15.6%) | 8 (9.9%) | |
| 10 or more | 14 (10.9%) | 3 (3.7%) |
*
Did not meet 2012 American College of Rheumatology (ACR) Sjögren’s syndrome (SS) classification criteria
**
Met 2012 ACR SS classification criteria
┼
From the worse eye of a specific ocular dry eye measure.
***
Actual tear break-up time was not recorded for those with a TBUT of 10 sec or greater, so the mean value could not be calculated.