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. Author manuscript; available in PMC: 2020 Nov 4.
Published in final edited form as: Curr Biol. 2019 Oct 24;29(21):3635–3646.e5. doi: 10.1016/j.cub.2019.08.079

Figure 2. Activation of Trh-GAL4+ neurons alters sleep structure by changing the probability of state transitions.

Figure 2.

(A) The cumulative distribution of daytime sleep episode durations for baseline (left), activation (middle) and recovery (right) days is shown. (B) Probability of transition from a sleep to an awake state, P(wake), is significantly decreased compared to controls during rebound sleep. (C) Probability of transition from an awake to a sleep state, P(doze), significantly increased upon activation of Trh-GAL4+ neurons. Data are presented as the absolute change from baseline day. (D) The percent of total sleep occurring in episodes >200 min was significantly reduced when Trh-GAL4+ neurons were activated. (E) The number of individuals with long episodes was decreased. Data in D and E are presented as mean + binomial standard error. (F-G) Trh-GAL4+ neurons exhibit a rhythmic daily activity pattern as visualized with a Tric-LUC reporter in two days. Data are presented as mean + SEM. See also Table S1–2, Figures S1–2.