Figure 3.

Proteins either strongly positively- or anti-correlated with histology-based predictions are significantly enriched in cancer-relevant molecular pathways. (A) List of Reactome pathways that are significantly associated with the proteins on the basis of their correlations with histology-based predictions, as detected by Gene Set Enrichment Analysis (GSEA) (Methods). Bars indicate the magnitude of the enrichment scores, and adjusted p-values of the enrichments are color coded. (B) and (C) show examples of pathways significantly associated with proteins highly positively- and anti-correlated with histology-based predictions respectively. In (B) and (C) proteins are ranked according to their correlations with the histology-based predictions, from highest to lowest, and pathway enrichment scores were estimated with GSEA.