Table 2.
Cytotoxicity of compounds 1, 2, 7, 9–15 in different human cell lines, measured at 24 h of incubation. IC50 (μg/mL).
| Entry | HepG2 | MCF-7 | RCC4-VA | RCC4-VHL | Fa2N4 |
|---|---|---|---|---|---|
| 1 | >20 | <1.25 | 14.19 | >20 | 12.09 |
| 2 | >20 | 4.42 | >20 | >20 | >20 |
| 7 | >20 | 13.52 | >20 | >20 | >20 |
| 9 | >20 | 1.93 | >20 | >20 | >20 |
| 10 | 14.20 | 3.59 | >20 | >20 | >20 |
| 11 | >20 | 11.26 | >20 | >20 | >20 |
| 12 | >20 | 3.78 | 6.02 | 8.00 | >20 |
| 13 | 17.48 | 2.15 | >20 | >20 | >20 |
| 14 | >20 | 5.22 | >20 | >20 | >20 |
| 15 | >20 | 2.03 | 17.14 | >20 | >20 |
HepG2 = liver cancer (CCL-8065); MCF-7 = breast carcinoma (HTB-22); RCC4-VA and –VHL = renal carcinoma; Fa2N4 = immortalized human hepatocytes.