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. 2019 Oct 16;24(20):3725. doi: 10.3390/molecules24203725

Figure 1.

Figure 1

Isoliquiritigenin (ISL) at a noncytotoxic concentration suppresses ovarian cancer cell epithelial-to-mesenchymal transition (EMT) traits. (A) Chemical structure of ISL. (B) The cell viability of SKOV3, OVCAR5, ES2, and TOV21G cells treated with ISL (2, 4, 8, 16, 32, 64, and 100 μM) for 72 h was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. (C) Observed cell morphology of cells treated with ISL (10 μM) for 72 h; 100× magnification. Scale bars, 25 μm. (D) Cells were treated with ISL (1, 5, and 10 μM) for 72 h and analyzed by Western blotting. (E) Bar graph shows results of quantitative analysis of Western blotting. Protein expression is presented as fold changes and normalized to β-actin. Data are presented as mean ± SD, n = 3. Student t-test was used for statistical tests. * p < 0.05, ** p < 0.01 compared with the control group.