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. 2019 Oct 5;11(10):918. doi: 10.3390/v11100918

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Immunization improves IFN-γ-secreting CD4+ and CD8+ T cell responses in mice. Two weeks after the second immunization, splenocytes from three mice in each group were cultured and stimulated with inactivated PPRV Nigeria 75/1. Mouse monoclonal antibodies against CD4, CD8, IFN-γ, and IL-4 were used to identify cells that were double-positive (a) CD4⁺ IFN-γ⁺, (b) CD4⁺ IL-4⁺, (c) CD8⁺ IFN-γ⁺, and (d) CD8⁺ IL-4⁺. Data were analyzed by one-way ANOVA and indicated as follows: * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001.