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. 2019 Nov 6;12:261. doi: 10.1186/s13068-019-1601-x

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Metabolic engineering E. coli monoculture for production of icariside D2 from glucose. a The genetic characteristics of strain BMT18 (DE3). Red crosses indicated the deleted genes. Darken bold arrows indicated the overexpressed genes (aroG^fbr, aroE, and tyrA^fbr) in the chromosome. Green arrows indicated the heterologous genes. G6P glucose 6-phosphate, G1P glucose 1-phosphate, E4P erythrose 4-phosphate, PEP phosphoenolpyruvate, PYR pyruvate, DAHP 3-deoxyarabino-heptulonate 7-phosphate, SHK shikimate, CHA chorismic acid, PHE phenylalanine, TYR tyrosine, fbr feedback inhibition resistance. b Fermentation of strain BMD8, derived from BMT18 (DE3) harboring two plasmids pLX2 and pLXD8. c Fermentation of strain BMD10, derived from BMT18 (DE3) harboring one plasmid pLXD9