Table 2.
HRs (95% CI) for all-cause, cardiovascular and cancer mortality stratified by baseline high-sensitivity C-reactive protein concentration quartiles
| HsCRP quartiles | All-cause mortality | Cardiovascular mortality | Cancer mortality | |||
|---|---|---|---|---|---|---|
| Model 1a | Model 2b | Model 1 | Model 2 | Model 1 | Model 2 | |
| No. of participants | 14,220 | 14,220 | 14,220 | |||
| Person-years at risk | 80,572 | 80,572 | 80,572 | |||
| No. of events | 1730 | 608 | 351 | |||
| Q1 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| Q2 | 1.02 (0.88–1.17) | 1.06 (0.92–1.22) | 1.07 (0.84–1.36) | 1.09 (0.82–1.33) | 1.05 (0.76–1.44) | 1.07 (0.78–1.48) |
| Q3 | 1.17 (1.02–1.35)* | 1.18 (1.03–1.36)* | 1.28 (1.01–1.62)* | 1.26 (1.00–1.57) | 1.23 (0.90–1.69) | 1.23 (0.90–1.69) |
| Q4 | 1.59 (1.40–1.82)*** | 1.50 (1.31–1.72)*** | 1.62 (1.29–2.04)*** | 1.44 (1.13–1.82)** | 1.71 (1.27–2.29)*** | 1.67 (1.23–2.26)** |
| P for trend | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 |
aModel 1: adjusted for age and sex
bModel 2: adjusted for age, sex, race, educational level, current smoking status, alcohol consumption, regular exercise, body mass index (BMI), household income, total cholesterol (TC) concentration, high density lipoprotein-cholesterol (HDL-C) concentration, hemoglobin A1c (HbA1c) at the endCES-D 8 score, hypertension, heart disease, stroke, diabetes, pulmonary disorder, psychiatric problems, and limitations in activities of daily living (ADLs)
* P < 0.05; ** P < 0.01; *** P < 0.001