Table 2.

Concentration of MEP intermediates compared to the K_m values of the downstream enzymes

Enzyme	Km (µM)	Concentration in E. coli (µM)
Dxs	226 GAPa	10.3b
Dxr	99c; 115d; 720e DXP	16.8 ± 0.7
IspD	61f; 370g MEP	0.75 ± 0.04
IspE	150h ME-CDP	0.92 ± 0.02
IspG	311i; 560–700j MEcPP	12.2 ± 0.01
Idi	~ 9.5/14.3k IPP/DMAPP	1.3 ± 0.2

^a [41]; ^b [40]; ^c [42]; ^d [43]; ^e [44]; ^f [48]; ^g [47]; ^h [54]; ⁱ [49]; ^j [55]; ^k [36]