Table 3.
Relative gene expression in 7 horses with mild equine asthma before and after treatment with 20 mg dexamethasone IM SID for 10 days. The normalization factor (calculated from multiple reference genes) has a value of 1, and genes of interest are either up-regulated or down-regulated in response to treatment. * indicate a significant difference (p < 0.05)
| Gene | Expression | Regulation | Standard Error | 95% C.I. | P value |
|---|---|---|---|---|---|
| IL-1β | 1.09 | UP | 0.26–4.83 | 0.07–8.74 | 0.77 |
| IL-4 | 1.82 | DOWN | 0.14–2.80 | 0.04–7.14 | 0.08 |
| IL-5 | 2.17 | DOWN | 0.11–2.15 | 0.05–8.88 | 0.048* |
| IL-6 | 2.23 | UP | 0.30–16.06 | 0.06–78.66 | 0.08 |
| IL-8 | 1.64 | UP | 0.45–6.16 | 0.19–16.62 | 0.06 |
| IL-10 | 1.31 | UP | 0.26–7.82 | 0.12–36.95 | 0.44 |
| IL-12 | 1.69 | DOWN | 0.15–2.90 | 0.07–6.04 | 0.12 |
| IL-17 | 1.08 | UP | 0.04–25.16 | 0.002–382.68 | 0.92 |
| IL-23 | 1.22 | DOWN | 0.30–2.50 | 0.11–7.32 | 0.41 |
| Eotaxin-2 | 1.16 | UP | 0.04–42.07 | 0.001–282.09 | 0.84 |
| TNF-α | 1.75 | DOWN | 0.19–1.69 | 0.07–3.55 | 0.023* |
| IFN-γ | 2.70 | DOWN | 0.01–10.68 | 0.01–22.52 | 0.21 |