Table 5.
Clinical characteristics of 55 patients with “long” CPB time (≥ 115 min)
| Variables | CONTROL | ROTEM® | p-value |
|---|---|---|---|
| Baseline values | |||
| Number, n (%) | 26 (47) | 29 (53) | |
| Age [years] | 66.9 ± 11.1 | 66.7 ± 10.0 | 0.87 |
| Male sex, n (%) | 22 (85) | 26 (90) | 0.70 |
| BMI | 24.5 [23.0;29.0] | 27.0 [25.0;29.5] | 0.07 |
| Log. EuroSCORE [%] | 10.2 ± 10.5 | 7.4 ± 6.9 | 0.40 |
| STS – Score [%] | 3.7 ± 3.9 | 3.3 ± 3.1 | 0.73 |
| Biplane LVEF [%] | 60.0 [41.5;65.0] | 59.0 [50.0;65.0] | 1.00 |
| Diabetes mellitus, n (%) | 7 (27) | 7 (24) | 1.00 |
| COPD, n (%) | 1 (4) | 5 (17) | 0.20 |
| Creatinine [mmol/l] | 98.0 [80.0;109.3] | 106.0 [86.5;130.5] | 0.07 |
| Deep hypothermic circulatory arrest, n (%) | 2 (8) | 1 (3) | 0.60 |
| Re-operation, n (%) | 2 (8) | 4 (14) | 0.67 |
| Perioperative details | |||
| CPB time [min] | 161.4 ± 59.8 | 159.3 ± 41.3 | 0.93 |
| Cross-clamp time [min] | 105.8 ± 41.9 | 99.3 ± 31.7 | 0.84 |
| Heparin [IU] | 31,528.0 ± 9526.2 | 34,925.9 ± 10,049.6 | 0.16 |
| Protamin [IU] | 30,720.0 ± 7924.2 | 31,000.0 ± 5699.1 | 0.46 |
| RBCs [units] | 1.4 ± 2.0 | 1.2 ± 2.1 | 0.45 |
| FFPs [units] | 1.2 ± 1.9 | 0.7 ± 1.2 | 0.52 |
| Platelet concentrates [units] | 0.3 ± 0.7 | 0.1 ± 0.4 | 0.20 |
| Fibrinogen [g] | 0.2 ± 0.7 | 0.1 ± 0.5 | 1.00 |
| PPSB [IU] | 200.0 ± 707.1 | 166.7 ± 500.0 | 1.00 |
| AT3, IU, mean ± SD | 200.0 ± 707.1 | 129.6 ± 429.5 | 1.00 |
| Aprotinin [Mio IU] | 0.6 ± 0.9 | 1.9 ± 9.6 | 0.03 |
| Tranexamic acid [g] | 1.6 ± 1.5 | 1.8 ± 1.5 | 1.00 |
| ACT (prior to ICU transfer) [sec] | 134.1 ± 16.1 | 130.7 ± 20.2 | 0.18 |
| Hct (prior to ICU transfer) [%] | 28.1 ± 4.4 | 28.4 ± 3.8 | 0.71 |
| Temperature (prior to ICU transfer) [°C] | 36.4 [36.0;36.6] | 36.3 [36.0;36.6] | 0.70 |
| Postoperative - ICU | |||
| RBCs [units] | 7.1 + 10.8 | 3.8 + 3.8 | 0.28 |
| FFPs [units] | 4.2 ± 5.6 | 1.7 ± 2.8 | 0.07 |
| Platelet concentrates [units] | 1.1 ± 1.3 | 0.4 ± 0.6 | 0.02 |
| Fibrinogen [g] | 0.2 ± 0.6 | 0.9 ± 1.2 | 0.01 |
| PPSB [IU] | 0.0 ± 0.0 | 0.0 ± 0.0 | 1.00 |
| AT3 [IU] | 40.0 ± 200.0 | 0.0 ± 0.0 | 0.48 |
| Aprotinin [Mio IU] | 0.4 ± 0.8 | 0.0 ± 0.0 | 0.02 |
| Tranexamic acid [g] | 0.1 ± 0.4 | 0.1 ± 0.4 | 1.00 |
| Blood loss within first 24 h [ml] | 2056.8 ± 974.5 | 1538.2 ± 806.4 | 0.03 |
| Re-thoracotomy, n (%) | 7 (27) | 6 (21) | 0.75 |
| 30-day mortality, n (%) | 3 (12) | 0 (0) | 0.10 |
| 5-year mortality, n (%) | 4 (15) | 0 (0) | 0.03 |
Data presented as numbers (%), mean ± SD or as median (interquartile range)