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. 2019 Oct 16;16(159):20190356. doi: 10.1098/rsif.2019.0356

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© 2019 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 12. — Reducing misfolding. The Heterodimer model predicts that lower turnover rates k₁₂ delay and reduce the accumulation of misfolded protein $\tilde{p}$ . Baseline Alzheimer’s disease (a) and Alzheimer’s disease with moderately (b) and markedly (c) reduced turnover k₁₂ from the healthy to the misfolded state. (Online version in colour.)