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. 2019 Oct 16;16(159):20190356. doi: 10.1098/rsif.2019.0356

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© 2019 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 19. — Reducing biomarker spectrum through size-targeted clearance. Increasing the clearance k_i of a single specific aggregate size delays and reduces the accumulation of misfolded tau protein c_i and with it the biomarker spectrum $M$ . Increasing the target size of clearance, here from c₂ to c₆ decelerates and reduces protein misfolding and narrows the overall size distribution. The red curves highlight the biomarker spectrum for the baseline model with a homogeneous clearance in figure 16. (Online version in colour.)