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. 2019 Sep 17;20:554–566. doi: 10.1016/j.isci.2019.09.020

Figure 3.

Figure 3

C286 Regulates DNA Damage in Microglia via BRCA1 and ATM Pathways

(A) Diagram showing microglia culture conditions and markers assessed.

(B–E) (B and C) BRCA1 and (D and E) γH2AX expression and quantification in microglia cultures.

(F) Diagram showing the experimental design.

(G and H) Expression and quantification of pATM in nuclei in the different culture conditions. Scale bars, 15 μm. Data show Mean FI ± SEM from three independent experiments (C and E), Student's t test, *p ≤ 0.05 and (H) one-way ANOVA with Pairwise Multiple Comparison Procedures (Tukey Test), ***p ≤ 0.001.