Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Implications of inflammaging-dependent shunt of Trp metabolism. Age-related decline of tissue homeostasis causes a physiological low-grade chronic inflammatory phenotype known as inflammaging. We hypothesize that Trp is metabolized toward the Kyn pathway in order to control age-related inflammation. Consequent disturbances of Trp and Kyn metabolites could be involved in age-related diseases and reduced lifespan.
